Article

Tbx1 functions in pharyngeal arch and cardiovascular development

2014-01-01

Abstract excerpt

<i>Tbx1</i>, a gene encoding a T-box transcription factor, is required for embryonic development in humans and mice. Half dosage of this gene causes most of the features of the DiGeorge or Velocardiofacial syndrome phenotypes, including aortic arch and cardiac outflow tract abnormalities. Here we show that genetic ablation of <i>Trp53</i> or pharmacological inhibition of its protein product p53 rescues almost comp...

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Literature Corpus work: e94c81aa-b8e7-5934-ad76-018e4743b8fd
DOI: 10.21954/ou.ro.0000ef0b

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