Article
Single-cell transcriptional diversity is a hallmark of developmental potential.
Science (New York, N.Y.) - 24 Jan 2020
Gulati Gunsagar S, Sikandar Shaheen S, Wesche Daniel J, Manjunath Anoop, Bharadwaj Anjan, Berger Mark J, Ilagan Francisco, Kuo Angera H, Hsieh Robert W, Cai Shang, Zabala Maider, Scheeren Ferenc A, Lobo Neethan A, Qian Dalong, Yu Feiqiao B, Dirbas Frederick M, Clarke Michael F, Newman Aaron M
Abstract excerpt
Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular differentiation trajectories. However, inferring both the state and direction of differentiation is challenging. Here, we demonstrate a simple, yet robust, determinant of developmental potential-the number of expressed genes per cell-and leverage this measure of transcriptional diversity to develop a computational framework...
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