Back to search

Article

Comparative single cell analysis of transcriptional bursting reveals the role of genome organization on <i>de novo</i> transcript origination

2024-04-29

Abstract excerpt

Spermatogenesis is a key developmental process underlying the origination of newly evolved genes. However, rapid cell type-specific transcriptomic divergence of the Drosophila germline has posed a significant technical barrier for comparative single-cell RNA-sequencing (scRNA-Seq) studies. By quantifying a surprisingly strong correlation between species- and cell type-specific divergence in three closely related...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4e35dd24-72ac-5123-b3b0-73a0eebdfec1
DOI
10.1101/2024.04.29.591771
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Comparative single cell analysis of transcriptional bursting reveals the role of genome organization on <i>de novo</i> transcript originationDOI 10.1101/2024.04.29.591771
Testis single-cell RNA-seq reveals the dynamics of <i>de novo</i> gene transcription and germline mutational bias in <i>Drosophila</i>Semantic proximity
Dichotomous transcriptome divergence at the cell-type level between the <i>Drosophila</i> male and female germlinesSemantic proximity
On the origin and evolution of <i>Drosophila</i> new genes during spermatogenesisSemantic proximity
Applications of single-cell RNA sequencing in spermatogenesis and molecular evolutionSemantic proximity
Widespread transcriptional scanning in the testis modulates gene evolution ratesSemantic proximity
Evolutionary innovations in germline biology of placental mammals revealed by transcriptomics of first wave spermatogenesis in opossumSemantic proximity
Single cell RNA sequencing of <i>D. pseudoobscura</i> testes reveals transcriptional signatures of heteromorphic spermatogenesisSemantic proximity
Emergent dynamics of adult stem cell lineages from single nucleus and single cell RNA-Seq of <i>Drosophila</i> testesSemantic proximity
Single-cell analysis identifies critical regulators of spermatogonial development and differentiation in cattle-yak bullsSemantic proximity
The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesisSemantic proximity
The molecular evolution of mammalian spermatogenesisSemantic proximity
What has single-cell RNA-seq taught us about mammalian spermatogenesis?Semantic proximity
Select a neighboring publication to make it the new centre.