Article

White matter integrity and nicotine dependence in smokers: evaluating vertical and horizontal pleiotropy

2020-12-11

Abstract excerpt

Smoking is a heritable behavior and nicotine dependency is complex mechanism supported by both positive and negative reinforcements. We hypothesized that cerebral white matter (WM) may mediate the individual dependency on nicotine integrity because its integrity is altered in smokers and shows dose-related response to nicotine administration. Two vertical and one horizontal pleiotropy pathways that combined indivi...

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Literature Corpus work: 608da40f-e775-588c-b73e-d9a9f8936cbe
DOI: 10.1101/2020.12.09.417899

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