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Article

Pathway analysis of smoking quantity in multiple GWAS identifies cholinergic and sensory pathways.

PloS one - 1 Jan 2012

Harari Oscar, Wang Jen-Chyong, Bucholz Kathleen, Edenberg Howard J, Heath Andrew, Martin Nicholas G, Pergadia Michele L, Montgomery Grant, Schrage Andrew, Bierut Laura J, Madden Pamela F, Goate Alison M

Abstract excerpt

Cigarette smoking is a common addiction that increases the risk for many diseases, including lung cancer and chronic obstructive pulmonary disease. Genome-wide association studies (GWAS) have successfully identified and validated several susceptibility loci for nicotine consumption and dependence. However, the trait variance explained by these genes is only a small fraction of the estimated genetic risk. Pathway...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23227220
DOI: 10.1371/journal.pone.0050913
PMCID: PMC3515482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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