Article
Protein Kinase C δ: a Gatekeeper of Immune Homeostasis.
Journal of clinical immunology - 1 Oct 2016
Salzer Elisabeth, Santos-Valente Elisangela, Keller Bärbel, Warnatz Klaus, Boztug Kaan
Abstract excerpt
Human autoimmune disorders present in various forms and are associated with a life-long burden of high morbidity and mortality. Many different circumstances lead to the loss of immune tolerance and often the origin is suspected to be multifactorial. Recently, patients with autosomal recessive mutations in PRKCD encoding protein kinase c delta (PKCδ) have been identified, representing a monogenic prototype for one...
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