Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Progressive Sub-MIC Exposure of Klebsiella pneumoniae 43816 to Cephalothin Induces the Evolution of Beta-Lactam Resistance without Acquisition of Beta-Lactamase Genes

10 May 2023

Abstract excerpt

Bacterial exposure to antibiotic concentrations below the minimum inhibitory concentration (MIC) may result in a selection window allowing for the rapid evolution of resistance. These sub-MIC concentrations are commonly found in soils and water supplies in the greater environment. This study aimed to evaluate the adaptive genetic changes in Klebsiella pneumoniae 43816 after prolonged but increasing sub-MIC levels...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Resistance in Bacteria
Share to Antibiotics Pharmacokinetics and Efficacy
Share to Pharmaceutical and Antibiotic Environmental Impacts

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37237790
DOI: 10.3390/antibiotics12050887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progressive Sub-MIC Exposure of Klebsiella pneumoniae 43816 to Cephalothin Induces the Evolution of Beta-Lactam Resistance without Acquisition of Beta-Lactamase GenesPMID 37237790Read ↗

Progressive sub-MIC Exposure of <i>Klebsiella pneumoniae</i> 43816 to Cephalothin Induces the Evolution of beta-lactam Resistance without Acquisition of beta-lactamase GenesSemantic proximity Read ↗

Evolutionary trajectories of β-lactam resistance in <i>Enterococcus faecalis</i> strainsSemantic proximity Read ↗

Evolutionary trajectories of β-lactam resistance in Enterococcus faecalis strains.Semantic proximity Read ↗

A review of the mechanisms that confer antibiotic resistance in pathotypes of E. coliSemantic proximity Read ↗

<i>De novo</i> acquisition of antibiotic resistance in six species of bacteriaSemantic proximity Read ↗

Subinhibitory concentrations of nalidixic acid alter bacterial physiology and induce anthropogenic resistance in a commensal strain of Escherichia coli in vitro.Semantic proximity Read ↗

Antibiotrophs: The complexity of antibiotic-subsisting and antibiotic-resistant microorganisms.Semantic proximity Read ↗

Environmental reservoir of resistance genes for the last resort antibiotic CefiderocolSemantic proximity Read ↗

Mutation-driven resistance development in wastewater E. coli upon low-level cephalosporins: Pharmacophore contribution and novel mechanism.Semantic proximity Read ↗

Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibioticsSemantic proximity Read ↗

Aminoglycoside heteroresistance in <i>Enterobacter cloacae</i> is driven by the cell envelope stress responseSemantic proximity Read ↗

Environmental dimensions of antibiotic resistance: assessment of basic science gapsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.