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Article

Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incretin-induced insulin secretion.

PloS one - 1 Jan 2017

Murao Naoya, Yokoi Norihide, Honda Kohei, Han Guirong, Hayami Tomohide, Gheni Ghupurjan, Takahashi Harumi, Minami Kohtaro, Seino Susumu

Abstract excerpt

Incretins (GLP-1 and GIP) potentiate insulin secretion through cAMP signaling in pancreatic β-cells in a glucose-dependent manner. We recently proposed a mechanistic model of incretin-induced insulin secretion (IIIS) that requires two critical processes: 1) generation of cytosolic glutamate through the malate-aspartate (MA) shuttle in glucose metabolism and 2) glutamate transport into insulin granules by cAMP...

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PMID: 29091932
DOI: 10.1371/journal.pone.0187213
PMCID: PMC5665537

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GIP

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