Article

Inhibition of SHP2 ameliorates psoriasis by decreasing TLR7 endosome localization

2020-09-30

Abstract excerpt

<h4>SUMMARY</h4> Psoriasis is a complex chronic inflammatory skin disease with unclear molecular mechanisms. Here, we identify Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) as a novel accelerator of psoriasis development. Both genetic ablation of SHP2 in macrophages and pharmacological inhibition of SHP2 prevents the development of psoriasis-like skin inflammation in an imiquimod-induced m...

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Literature Corpus work: 60048832-e2fb-5ab5-a05a-3bac43760dc9
DOI: 10.1101/2020.09.28.20202861

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