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Article

PI3Kδ Sustains Keratinocyte Hyperproliferation and Epithelial Inflammation: Implications for a Topically Druggable Target in Psoriasis.

Cells - 2 Oct 2021

Mercurio Laura, Morelli Martina, Scarponi Claudia, Scaglione Giovanni Luca, Pallotta Sabatino, Albanesi Cristina, Madonna Stefania

Abstract excerpt

The phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway is aberrantly activated in psoriatic lesions and contributes to disease pathogenesis. Among PI3Ks enzymes, PI3Kα, β, and δ isoforms are known to bind the p85 regulatory subunit and mediate activation of AKT and other downstream effectors. In this study, we deepened our understanding of the expression and function of PI3Kδ in skin lesions of...

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Identifiers

PMID: 34685616
DOI: 10.3390/cells10102636
PMCID: PMC8534452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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