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HECT and RING finger families of E3 ubiquitin ligases at a glance

1 Feb 2012

Abstract excerpt

The post-translational attachment of ubiquitin, a highly conserved 76-amino-acid polypeptide, directs myriad eukaryotic proteins to a variety of fates and functions. Ubiquitylation is best-known for targeting proteins for degradation by the 26S proteasome. Other functions include internalization and lysosomal targeting, modulation of protein interactions, alteration of subcellular distribution, regulation of...

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PMID: 22389392
DOI: 10.1242/jcs.091777

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