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Article

Cardiac Sodium Channel Mutations: Why so Many Phenotypes?

Current topics in membranes - 1 Jan 2016

Liu M, Yang K-C, Dudley S C

Abstract excerpt

The cardiac Na(+) channel (Nav1.5) conducts a depolarizing inward Na(+) current that is responsible for the generation of the upstroke Phase 0 of the action potential. In heart tissue, changes in Na(+) currents can affect conduction velocity and impulse propagation. The cardiac Nav1.5 is also involved in determination of the action potential duration, since some channels may reopen during the plateau phase,...

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Identifiers

PMID: 27586294
DOI: 10.1016/bs.ctm.2015.12.004
PMCID: PMC8597931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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