Article

A computational approach to demonstrate the control of gene expression via chromosomal access in colorectal cancer

2023-06-01

Abstract excerpt

Improved technologies for chromatin accessibility sequencing such as ATAC-seq have increased our understanding of gene regulation mechanisms, particularly in disease conditions such as cancer. This study introduces a computational tool that quantifies and establishes connections between chromatin accessibility, transcription factor binding, transcription factor mutations, and gene expression using publicly availab...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5fb4f5e6-f0a3-5251-9110-a213b0ca82f2
DOI: 10.21203/rs.3.rs-2981903/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A computational approach to demonstrate the control of gene expression via chromosomal access in colorectal cancerDOI 10.21203/rs.3.rs-2981903/v1Read

Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancersSemantic proximity Read

Allelic imbalance of chromatin accessibility in cancer identifies candidate causal risk variants and their mechanisms.Semantic proximity Read

ALTRE: workflow for defining ALTered Regulatory Elements using chromatin accessibility dataSemantic proximity Read

Deep learning with implicit handling of tissue-specific phenomena predicts tumor DNA accessibility and immune activitySemantic proximity Read

Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibilitySemantic proximity Read

Reproducible processing of TCGA regulatory networksSemantic proximity Read

Profiling chromatin accessibility in formalin-fixed paraffin-embedded samplesSemantic proximity Read

Detecting Differential Transcription Factor Activity from ATAC-Seq Data.Semantic proximity Read

Pancreatic cancer prognosis is predicted by a novel ATAC-array technology for assessing chromatin accessibilitySemantic proximity Read

Quality assessment and refinement of chromatin accessibility data using a sequence-based predictive modelSemantic proximity Read

Expression QTL-based analyses reveal the mechanisms underlying colorectal cancer predisposition.Semantic proximity Read

Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networksSemantic proximity Read