Back to search

Article

Molecular pharmacodynamics of amoxicillin-clavulanic acid against Escherichia coli

2025-12-10

Abstract excerpt

<title>Abstract</title> <p> Amoxicillin-clavulanic acid (AMX-CLV) is a widely used oral β-lactam/β-lactamase inhibitor combination against <italic>Escherichia coli</italic> . Clinical success is largely confined to urinary tract infections. The mechanistic basis for this site-specific efficacy remains unclear. Using a hollow-fibre infection model to replicate human plasma and urinary pharmacokinetics, we show...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
54cb3b64-8006-5f8b-afec-819f870e4217
DOI
10.21203/rs.3.rs-8148425/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Molecular pharmacodynamics of amoxicillin-clavulanic acid against Escherichia coliDOI 10.21203/rs.3.rs-8148425/v1
Antibiotic exposure elicits the emergence of colistin- and carbapenem-resistant Escherichia coli coharboring MCR-1 and NDM-5 in a patientSemantic proximity
Uropathogenic Escherichia coli (UPEC)-Associated Urinary Tract Infections: The Molecular Basis for Challenges to Effective TreatmentSemantic proximity
Pangenome Analysis of <i>Proteus mirabilis</i> Reveals Lineage-Specific Antimicrobial Resistance Profiles and Discordant Genotype-Phenotype CorrelationsSemantic proximity
Rapid clinical metagenomics enables early tailored therapy in complicated urinary tract infections and strengthens antimicrobial stewardshipSemantic proximity
Phylogenomics, Epigenomics, Virulome, and Mobilome of Gram-negative Bacteria Co-resistant to Carbapenems and Polymyxins: A One-Health Systematic Review and Meta-analysesSemantic proximity
Amoxicillin exposure significantly increases the population and virulence of antibiotic-resistant Klebsiella pathogen in the simulated human intestinal microbiotaSemantic proximity
Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistanceSemantic proximity
A review of the mechanisms that confer antibiotic resistance in pathotypes of E. coliSemantic proximity
Prolonged Antibiotic Treatment Generates a Fluoroquinolone Resistant Gut Microbiome and Collateral Multi-Drug ResistanceSemantic proximity
Antimicrobial resistance and beta-lactamase gene distribution among clinical isolates: a two-year cohort studySemantic proximity
In-hospital areas with distinct maintenance and staff/patient traffic have specific microbiome profiles, functions, and resistomesSemantic proximity
Antibiotic Contamination and AMR Dynamics in the Urban Sewage Microbiome: Insights from a Longitudinal surveillanceSemantic proximity
Select a neighboring publication to make it the new centre.