Article

Gram-positive bacteria secrete RNA aptamers to activate human STING for IL-1β release

2021-07-21

Abstract excerpt

<h4>ABSTRACT</h4> Molecular mechanisms through which Gram-positive bacteria induce the canonical inflammasome are poorly understood. Here, we studied the effects of Group B streptococci (GBS) and Staphylococcus aureus (SA) on inflammasome activation in human macrophages. Dinucleotide binding small RNA aptamers released by SA and GBS were shown to trigger increased IL-1β generation by inflammasomes. The stimulato...

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Literature Corpus work: 5f7ea76f-61c4-585a-8db6-899cf55e3d52
DOI: 10.1101/2021.07.21.453173

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