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Article

Signal inhibitory receptor on leukocytes‐1 recognizes bacterial and endogenous amphipathic α‐helical peptides

17 Sept 2021

Abstract excerpt

Signal inhibitory receptor on leukocytes-1 (SIRL-1) is a negative regulator of myeloid cell function and dampens antimicrobial responses. We here show that different species of the genus Staphylococcus secrete SIRL-1-engaging factors. By screening a library of single-gene transposon mutants in Staphylococcus aureus, we identified these factors as phenol-soluble modulins (PSMs). PSMs are amphipathic α-helical...

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Identifiers

PMID: 34533845
DOI: 10.1096/fj.202100812r

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