Article

Selection for immune evasion in SARS-CoV-2 revealed by high-resolution epitope mapping combined with genome sequence analysis

2022-06-02

Abstract excerpt

<h4>ABSTRACT</h4> A deeper understanding of the molecular determinants that drive humoral responses to coronaviruses, and in particular severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is critical for improving and developing diagnostics, therapies and vaccines. Moreover, viral mutations can change key antigens in a manner that alters the ability of the immune system to detect and clear infections. I...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4040a809-dc25-5af1-9978-ebe5fab2d99c
DOI: 10.1101/2022.06.01.494373

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Selection for immune evasion in SARS-CoV-2 revealed by high-resolution epitope mapping combined with genome sequence analysisDOI 10.1101/2022.06.01.494373Read

The landscape of antibody binding in SARS-CoV-2 infectionSemantic proximity Read

Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronavirusesSemantic proximity Read

The T cell epitope landscape of SARS-CoV-2 variants of concernSemantic proximity Read

Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with an endemic human CoVSemantic proximity Read

COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2Semantic proximity Read

Viral population genomics reveals host and infectivity impact on SARS-CoV-2 adaptive landscapeSemantic proximity Read

Investigation of Immunoreactivity Profiles and Epitope Landscape in Divergent COVID-19 Trajectories and SARS-CoV-2 Variants.Semantic proximity Read

High seroreactivity against SARS-CoV-2 Spike epitopes in a pre SARS-CoV-2 cohort: implications for antibody testing and vaccine designSemantic proximity Read

Predicted CTL responses from pressured epitopes in SARS-CoV-2 correlate with COVID-19 severitySemantic proximity Read

T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome.Semantic proximity Read

SARS-CoV-2 epitope-specific T cells: Immunity response feature, TCR repertoire characteristics and cross-reactivitySemantic proximity Read

Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVIDSemantic proximity Read