Article

Capturing cell type-specific chromatin structural patterns by applying topic modeling to single-cell Hi-C data

2019-01-30

Abstract excerpt

Single-cell Hi-C (scHi-C) interrogates genome-wide chromatin interaction in individual cells, allowing us to gain insights into 3D genome organization. However, the extremely sparse nature of scHi-C data poses a significant barrier to analysis, limiting our ability to tease out hidden biological information. In this work, we approach this problem by applying topic modeling to scHi-C data. Topic modeling is well-su...

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Literature Corpus work: 5f6346a0-b967-5b95-a4f1-76b675cc0a73
DOI: 10.1101/534800

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