Article

Tree-structured topic modelling of single-cell gene expression data uncovers hierarchical relationships between immune cell types

2023-11-06

Abstract excerpt

Immune cells undergo a series of differentiation steps following a lineage-tree structure stemming from hematopoietic stem cells. During differentiation of immune cells in both homeostasis and pathological processes, many gene regulatory mechanisms are shared by fully differentiated immune cell sub-types. In order to characterize these features quantitatively, we propose LaRCH , a tree-structured embedded topic m...

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Literature Corpus work: c9c48a29-9847-58b1-a160-b4ea68e1b768
DOI: 10.1101/2023.11.06.565879

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