Article

Intracellular pathogen targeting by IL32 elicits cell-autonomous immunity

2026-07-25

Abstract excerpt

Interferon-γ safeguards humans against intracellular pathogens, yet how most interferon-stimulated genes protect host cells, and how human-adapted pathogens evade these defenses is unclear 1,2 . Here, we discover a potent immune surveillance and effector circuit executed by an intracellularly acting cytokine, IL32, that targets and restricts phylogenetically distinct vacuolar pathogens, including the bacterium C...

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Identifiers and source

Literature Corpus work: 5f60c295-ef70-5c2e-bce3-81c2618208c2
DOI: 10.64898/2026.07.21.739902

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