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Inducible nitric oxide synthase (iNOS) is necessary for GBP-mediated <i>T. gondii</i> restriction in murine macrophages via vacuole nitration and intravacuolar network collapse

2023-07-25

Abstract excerpt

Toxoplasma gondii is an obligate intracellular, protozoan pathogen of rodents and humans. T. gondii’s ability to grow within cells and evade cell-autonomous immunity depends on the integrity of the parasitophorous vacuole (PV). Interferon-inducible guanylate binding proteins (GBPs) are central mediators of T. gondii clearance, however, the precise mechanism linking GBP recruitment to the PV and T. gondii restri...

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Identifiers and source

Literature Corpus work
0405f27e-fb4a-55dd-b1d2-38115c79e134
DOI
10.1101/2023.07.24.549965
Open publication

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Inducible nitric oxide synthase (iNOS) is necessary for GBP-mediated <i>T. gondii</i> restriction in murine macrophages via vacuole nitration and intravacuolar network collapseDOI 10.1101/2023.07.24.549965
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