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Simultaneous Transcriptional Profiling of Bacteria and Their Host Cells

4 Dec 2013

Abstract excerpt

We developed an RNA-Seq-based method to simultaneously capture prokaryotic and eukaryotic expression profiles of cells infected with intracellular bacteria. As proof of principle, this method was applied to Chlamydia trachomatis-infected epithelial cell monolayers in vitro, successfully obtaining transcriptomes of both C. trachomatis and the host cells at 1 and 24 hours post-infection. Chlamydiae are obligate...

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Clostridium difficile and Clostridium perfringens research
Gut microbiota and health
Reproductive tract infections research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24324615
DOI: 10.1371/journal.pone.0080597

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