Article

Host cyclophilin-mediated maturation of an obligate intracellular bacterial surface virulence factor

2025-10-28

Abstract excerpt

Adaptation of obligate intracellular bacteria to the eukaryotic cytoplasm creates dependencies on host factors that comprise unique infection mechanisms and vulnerabilities compared to facultative intracellular species. Here, we identify the peptidylprolyl isomerase cyclophilin A (PPIA/CypA) as a convergent host dependency in obligate intracellular bacterial pathogens. Using a host-directed functional genetic scre...

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Literature Corpus work: 57f3f852-b52b-5f80-b610-4c2a0c999486
DOI: 10.1101/2025.10.28.684717

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