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Article

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis.

Nature communications - 25 Apr 2017

Yeung Amy T Y, Hale Christine, Lee Amy H, Gill Erin E, Bushell Wendy, Parry-Smith David, Goulding David, Pickard Derek, Roumeliotis Theodoros, Choudhary Jyoti, Thomson Nick, Skarnes William C, Dougan Gordon, Hancock Robert E W

Abstract excerpt

Chlamydia trachomatis remains a leading cause of bacterial sexually transmitted infections and preventable blindness worldwide. There are, however, limited in vitro models to study the role of host genetics in the response of macrophages to this obligate human pathogen. Here, we describe an approach using macrophages derived from human induced pluripotent stem cells (iPSdMs) to study macrophage-Chlamydia...

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Identifiers

PMID: 28440293
DOI: 10.1038/ncomms15013
PMCID: PMC5414054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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