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Article

Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma.

Cancer cell - 9 Nov 2020

Dong Rui, Yang Ran, Zhan Yong, Lai Hua-Dong, Ye Chun-Jing, Yao Xiao-Ying, Luo Wen-Qin, Cheng Xiao-Mu, Miao Ju-Ju, Wang Jun-Feng, Liu Bai-Hui, Liu Xiang-Qi, Xie Lu-Lu, Li Yi, Zhang Man, Chen Lian, Song Wei-Chen, Qian Wei, Gao Wei-Qiang, Tang Yun-Hui, Shen Chun-Yan, Jiang Wei, Chen Gong, Yao Wei, Dong Kui-Ran, Xiao Xian-Min, Zheng Shan, Li Kai, Wang Jia

Abstract excerpt

Neuroblastoma (NB), which is a subtype of neural-crest-derived malignancy, is the most common extracranial solid tumor occurring in childhood. Despite extensive research, the underlying developmental origin of NB remains unclear. Using single-cell RNA sequencing, we generate transcriptomes of adrenal NB from 160,910 cells of 16 patients and transcriptomes of putative developmental cells of origin of NB from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32946775
DOI: 10.1016/j.ccell.2020.08.014

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