Article

Tricyclic and tetracyclic antidepressants upregulate VMAT2 activity and rescue disease-causing VMAT2 variants

2023-10-12

Abstract excerpt

Vesicular monoamine transporter 2 (VMAT2) is an essential transporter that regulates brain monoamine transmission and is important for mood, cognition, motor activity, and stress regulation. However, VMAT2 remains underexplored as a pharmacological target. In this study, we report that tricyclic and tetracyclic antidepressants acutely inhibit, but persistently upregulate VMAT2 activity by promoting VMAT2 protein m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5f36fccc-77b9-55cc-911d-434c0cdfa4c9
DOI: 10.1101/2023.10.09.561601

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tricyclic and tetracyclic antidepressants upregulate VMAT2 activity and rescue disease-causing VMAT2 variantsDOI 10.1101/2023.10.09.561601Read

Vesicular monoamine transporter (VMAT) regional expression and roles in pathological conditionsSemantic proximity Read

Genetic variants in the vesicular monoamine transporter 1 (VMAT1/SLC18A1) and neuropsychiatric disorders.Semantic proximity Read

Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis.Semantic proximity Read

N-terminus regulation of VMAT2 mediates methamphetamine-stimulated efflux.Semantic proximity Read

Disruptive mutations in the serotonin transporter associate serotonin dysfunction with treatment-resistant affective disorderSemantic proximity Read

hVMAT2: A Target of Individualized Medication for Parkinson's Disease.Semantic proximity Read

Brain dopamine-serotonin vesicular transport disease and its treatment.Semantic proximity Read

Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single‐Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) LigandsSemantic proximity Read

SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine.Semantic proximity Read

Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease.Semantic proximity Read

Identification and characterization of potent and selective inhibitors for the B <sup>0</sup> AT2/SLC6A15 amino acid transporterSemantic proximity Read

Thr136Ile polymorphism of human vesicular monoamine transporter-1 (SLC18A1 gene) influences its transport activity in vitro.Semantic proximity Read