Article

Identification and characterization of potent and selective inhibitors for the B <sup>0</sup> AT2/SLC6A15 amino acid transporter

2025-03-25

Abstract excerpt

1. The gene SLC6A15 encodes the protein B 0 AT2, a transporter for neutral amino acids. It is highly expressed in the brain and has been associated with depression but little is otherwise know about its function. In this study, we identified the first inhibitors of this protein to pharmacologically investigate its function. The transporter activity was evaluated using a cellular uptake of the substrate 3 H-prol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ba93d859-b6a7-5662-9493-9b466b053167
DOI: 10.1101/2025.03.25.645215

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification and characterization of potent and selective inhibitors for the B <sup>0</sup> AT2/SLC6A15 amino acid transporterDOI 10.1101/2025.03.25.645215Read

B(0)AT2 (SLC6A15) is localized to neurons and astrocytes, and is involved in mediating the effect of leucine in the brain.Semantic proximity Read

Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications.Semantic proximity Read

The SLC6A15–SLC6A20 Neutral Amino Acid Transporter Subfamily: Functions, Diseases, and Their Therapeutic RelevanceSemantic proximity Read

Structure and function of sodium-coupled GABA and glutamate transporters.Semantic proximity Read

SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine.Semantic proximity Read

Structural bioinformatics studies of serotonin, dopamine and norepinephrine transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F.Semantic proximity Read

Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric diseaseSemantic proximity Read

Zn2+ modulation of neurotransmitter transporters.Semantic proximity Read

Structural bioinformatics studies of glutamate transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F.Semantic proximity Read

Vesicular monoamine transporter (VMAT) regional expression and roles in pathological conditionsSemantic proximity Read

4 Phenylbutyrate Plus Gene augmentation: A Dual Therapy To Rescue of SLC6A1 Variant Associated Developmental And Epileptic EncephalopathySemantic proximity Read

Divergent metabolomic signatures by LAT1 and LAT2 amino acid transporters and characterization of biased LAT1 inhibitors and mutationsSemantic proximity Read