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Article

Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis.

Proceedings of the National Academy of Sciences of the United States of America - 22 Nov 2016

Yaffe Dana, Vergara-Jaque Ariela, Forrest Lucy R, Schuldiner Shimon

Abstract excerpt

Neurotransporters located in synaptic vesicles are essential for communication between nerve cells in a process mediated by neurotransmitters. Vesicular monoamine transporter (VMAT), a member of the largest superfamily of transporters, mediates transport of monoamines to synaptic vesicles and storage organelles in a process that involves exchange of two H+ per substrate. VMAT transport is inhibited by the...

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PMID: 27821772
DOI: 10.1073/pnas.1605162113
PMCID: PMC5127352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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