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Article

Brain dopamine-serotonin vesicular transport disease and its treatment.

The New England journal of medicine - 7 Feb 2013

Rilstone Jennifer J, Alkhater Reem A, Minassian Berge A

Abstract excerpt

We describe a disease encompassing infantile-onset movement disorder (including severe parkinsonism and nonambulation), mood disturbance, autonomic instability, and developmental delay, and we describe evidence supporting its causation by a mutation in SLC18A2 (which encodes vesicular monoamine transporter 2 [VMAT2]). VMAT2 translocates dopamine and serotonin into synaptic vesicles and is essential for motor...

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Identifiers

PMID: 23363473
DOI: 10.1056/NEJMoa1207281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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