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Article

Sodium-dependent reorganization of the sugar-binding site of SGLT1.

Biochemistry - 20 Nov 2007

Hirayama Bruce A, Loo Donald D F, Díez-Sampedro Ana, Leung Daisy W, Meinild Anne-Kristine, Lai-Bing Mary, Turk Eric, Wright Ernest M

Abstract excerpt

The sodium-dependent glucose cotransporter SGLT1 undergoes a series of voltage- and ligand-induced conformational changes that underlie the cotransport mechanism. In this study we describe how the binding of external Na changes the conformation of the sugar-binding domain, exposing residues that are involved in sugar recognition to the external environment. We constructed 15 individual Cys mutants in the four...

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Identifiers

PMID: 17960916
DOI: 10.1021/bi701562k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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