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Article

Structural Basis of the Selective Sugar Transport in Sodium-Glucose Cotransporters.

Journal of molecular biology - 15 Mar 2022

Kamitori Kazuyo, Shirota Matsuyuki, Fujiwara Yuichiro

Abstract excerpt

Sodium-glucose cotransporters (SGLTs) are responsible for sugar absorption in small intestine and renal tubule epithelial cells. These proteins have attracted clinical attention as a cause of malabsorption and as a target for diabetes drugs. Each SGLT isoform has strict selectivity for its monosaccharide substrate. Few studies have attempted to elucidate the structural basis of sugar selectivity by allowing...

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Identifiers

PMID: 35077764
DOI: 10.1016/j.jmb.2022.167464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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