Article
Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network.
Proteomics - 1 Jul 2016
Gnad Florian, Wallin Jeffrey, Edgar Kyle, Doll Sophia, Arnott David, Robillard Liliane, Kirkpatrick Donald S, Stokes Matthew P, Vijapurkar Ulka, Hatzivassiliou Georgia, Friedman Lori S, Belvin Marcia
Abstract excerpt
The PI3K pathway is commonly activated in cancer. Only a few studies have attempted to explore the spectrum of phosphorylation signaling downstream of the PI3K cascade. Such insight, however, is imperative to understand the mechanisms responsible for oncogenic phenotypes. By applying MS-based phosphoproteomics, we mapped 2509 phosphorylation sites on 1096 proteins, and quantified their responses to activation or...
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