Article

SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage

2021-08-05

Abstract excerpt

For efficient cell entry and membrane fusion, SARS-CoV-2 spike (S) protein needs to be cleaved at two different sites, S1/S2 and S2’ by different cellular proteases such as furin and TMPRSS2. Polymorphisms in the S protein can affect cleavage, viral transmission, and pathogenesis. Here, we investigated the role of arising S polymorphisms in vitro and in vivo to understand the emergence of SARS-CoV-2 variants. Fi...

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Literature Corpus work: 5ef849b8-6354-5a03-9fab-5487178ff3bd
DOI: 10.1101/2021.08.05.455290

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