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Role of Q675H Mutation in Improving SARS-CoV-2 Spike Interaction with the Furin Binding Pocket.

Viruses - 14 Dec 2021

Bertelli Anna, D'Ursi Pasqualina, Campisi Giovanni, Messali Serena, Milanesi Maria, Giovanetti Marta, Ciccozzi Massimo, Caccuri Francesca, Caruso Arnaldo

Abstract excerpt

Genotype screening was implemented in Italy and showed a significant prevalence of new SARS-CoV-2 mutants carrying Q675H mutation, near the furin cleavage site of spike protein. Currently, this mutation, which is expressed on different SARS-CoV-2 lineages circulating worldwide, has not been thoughtfully investigated. Therefore, we performed phylogenetic and biocomputational analysis to better understand...

Topics

Binding Sites
Furin
Genetic Fitness
Humans
Hydrogen Bonding
Molecular Dynamics Simulation
Mutation
Phylogeny
Protein Binding
Protein Conformation
SARS-CoV-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spike Glycoprotein, Coronavirus

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Open in PubMed Open full text

Identifiers

PMID: 34960779
DOI: 10.3390/v13122511
PMCID: PMC8705554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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