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Article

The impact of S2 mutations on Omicron SARS-CoV-2 cell surface expression and fusogenicity.

Emerging microbes & infections - 1 Dec 2024

Escalera Alba, Laporte Manon, Turner Sam, Karakus Umut, Gonzalez-Reiche Ana S, van de Guchte Adriana, Farrugia Keith, Khalil Zain, van Bakel Harm, Smith Derek, García-Sastre Adolfo, Aydillo Teresa

Abstract excerpt

SARS-CoV-2 Omicron subvariants are still emerging and spreading worldwide. These variants contain a high number of polymorphisms in the spike (S) glycoprotein that could potentially impact their pathogenicity and transmission. We have previously shown that the S:655Y and P681H mutations enhance S protein cleavage and syncytia formation. Interestingly, these polymorphisms are present in Omicron S protein. Here, we...

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Identifiers

PMID: 38112266
DOI: 10.1080/22221751.2023.2297553
PMCID: PMC10866063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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