Article

Controls-Only Quality Control Metric from Early GWAS Can Attenuate Gene-Sex Interaction Signals in Contemporary Large-Scale Studies

2026-07-27

Abstract excerpt

The gene-sex association quality control (QC) metric was developed during the era of early small-sized genome-wide association studies and typically filter variants based on controls alone. While this practice had minimal impact in early studies, in contemporary large-scale settings they can introduce systematic bias by disproportionately discarding variants with pronounced sex differences in allele frequencies (A...

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Literature Corpus work: 5ec9dfca-37a6-58ab-b9d1-a368e2b00c95
DOI: 10.64898/2026.07.22.26358697

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