Article

De Novo Variation in Autism by Sex and Diagnostic Status in 41,367 Parent-Child Trios

2026-01-29

Abstract excerpt

<h4>ABSTRACT</h4> Autism shows a consistent sex bias, yet how sex shapes de novo variant (DNV) risk across coding and noncoding sequence remains unclear. We analyzed DNVs in 41,367 parent-child sequenced trios from three autism family-based cohorts and compared DNV characteristics and enrichment patterns in males and females. Importantly, these trios consisted of some trios with individuals with autism and some...

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Literature Corpus work: 6aadaa05-97c2-566c-b68c-39ac93d590c9
DOI: 10.64898/2026.01.26.26344889

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