Biological sex affects gene expression and functional variation across the human genome

Abstract excerpt

<h4>Summary</h4> Humans display sexual dimorphism across many traits, but little is known about underlying genetic mechanisms and impacts on disease. We utilized single-cell RNA-seq of 480 lymphoblastoid cell lines to identify 1200 genes with significantly sex-biased expression. While reproducibility was highest among LCL datasets, 71% were found to be sex-biased in at least one GTEx tissue, with a core dataset o...

Topics

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• Chromosomes, Human, X
• Gene Expression Regulation
• Genetic Predisposition to Disease
• Quantitative Trait Loci
• Sex Characteristics
• Sex Factors
• Single-Cell Gene Expression Analysis
• Transcription Factors

Identifiers and source

Literature Corpus work

c651d6d0-b6ee-578c-996c-6b7765cc23c1

DOI

10.1101/2024.09.03.24313025