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Article

Pleiotropic Mechanisms Indicated for Sex Differences in Autism.

PLoS genetics - 1 Nov 2016

Mitra Ileena, Tsang Kathryn, Ladd-Acosta Christine, Croen Lisa A, Aldinger Kimberly A, Hendren Robert L, Traglia Michela, Lavillaureix Alinoë, Zaitlen Noah, Oldham Michael C, Levitt Pat, Nelson Stanley, Amaral David G, Hertz-Picciotto Irva, Fallin M Daniele, Weiss Lauren A

Abstract excerpt

Sexual dimorphism in common disease is pervasive, including a dramatic male preponderance in autism spectrum disorders (ASDs). Potential genetic explanations include a liability threshold model requiring increased polymorphism risk in females, sex-limited X-chromosome contribution, gene-environment interaction driven by differences in hormonal milieu, risk influenced by genes sex-differentially expressed in early...

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Share to Autism Spectrum Disorder
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child Development Disorders, Pervasive

Share to Chromosomes, Human, X

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Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 27846226
DOI: 10.1371/journal.pgen.1006425
PMCID: PMC5147776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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