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Loss of retinal stem cell reserve and lipofuscin accumulation accelerates cone-rod degeneration and replicates Stargardt disease in abca4b null zebrafish

2025-08-27

Abstract excerpt

<title>Abstract</title> Mutations in <italic>ABCA4</italic> gene causes Stargardt macular degeneration, which manifests with toxic lipofuscin deposits in the outer retina, gradual atrophy of RPE cells, followed by photoreceptor cell loss. The cone-enriched retina, with macula-like ‘area-temporalis’ of zebrafish are better models than rodents for studying human macular dystrophies. Here, we generated <ital...

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Literature Corpus work: 5ea3e3a5-e405-5446-912e-eb2f605a6705
DOI: 10.21203/rs.3.rs-7346082/v1

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