Article

Abca4 inhibition in the cone-rich rodent Psammomys obesus leads to Stargardts Disease type 1-like retinal degeneration

2024-05-14

Abstract excerpt

<title>Abstract</title> <p>Mutations in the gene ABCA4 coding for photoreceptor-specific ATP-binding cassette subfamily A member 4, are responsible for Stargardts Disease type 1 (STGD1), the most common form of inherited macular degeneration. STGD1 typically declares early in life and leads to severe visual handicap. Abca4 gene deletion mouse models of STGD1 accumulate lipofuscin, a hallmark of the disease, but u...

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Literature Corpus work: c193c00f-9a29-5806-9926-b6ff38933812
DOI: 10.21203/rs.3.rs-4292272/v1

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