Article

Abca4 inhibition in a cone-rich rodent leads to Stargardt Disease type 1-like retinal degeneration

2023-09-06

Abstract excerpt

Mutations in the gene ABCA4 coding for photoreceptor-specific A TP- b inding c assette subfamily A member 4 , are responsible for the most common form of inherited macular degeneration known as Stargardt Disease type 1 (STGD1). STGD1 typically declares early in life and leads to severe visual handicap. Abca4 gene deletion mouse models of STGD1 show increased accumulation of lipofuscin, a hallmark of the dis...

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Literature Corpus work: 004fc88d-dfe9-561c-adf3-cfd36887e740
DOI: 10.1101/2023.09.04.556201

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