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Article

Loss of retinal stem cell reserve and lipofuscin accumulation accelerates cone-rod degeneration and replicates Stargardt disease in abca4b null zebrafish.

Scientific reports - 21 Nov 2025

Pidishetty Divya, Damera Santhosh Kumar, Murugavel Murali, Susaimanickam Praveen Joseph, Chittajallu Sai Naga Sri Harsha, Kushawah Gopal, Sarkar Puja, Bharadwaj Shrikant R, Mishra Rakesh, Mariappan Indumathi

Abstract excerpt

Mutations in ABCA4 gene causes Stargardt macular degeneration, which manifests with toxic lipofuscin deposits in the outer retina, gradual atrophy of RPE cells, followed by photoreceptor cell loss. The cone-enriched retina, with macula-like ‘area-temporalis’ of zebrafish are better models than rodents for studying human macular dystrophies. Here, we generated abca4b knockout zebrafish model using CRISPR/Cas9...

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Source

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Identifiers

PMID: 41272236
DOI: 10.1038/s41598-025-28951-1
PMCID: PMC12749496

Genes

RPE
ABCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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