Article

Age-Related Decline in NCKX4-Mediated Calcium Clearance Accelerates Aortic Remodeling and Drives Early Vascular Aging

2025-10-03

Abstract excerpt

Aging is the primary nonmodifiable risk factor for cardiovascular diseases (CVDs), with older women facing a greater risk of CVDs than age-matched men. Vascular smooth muscle cells (VSMCs) dysfunction and impaired calcium (Ca 2+ ) handling are recognized as central contributors to arterial stiffening and calcification. However, the molecular and functional determinants of Ca 2+ clearance in vascular aging remain...

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Literature Corpus work: 5e9043ec-a7ad-5e79-8a6d-a8d1b81d56dd
DOI: 10.1101/2025.10.01.679848

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