Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus

Abstract excerpt

Abstract Autoreactive B cells have a major function in autoimmunity. A small subset of B cells expressing two distinct B-cell-antigen-receptors (B 2R cells) is elevated in many patients with systematic lupus erythematosus (SLE) and in the MRL(/ lpr ) mouse model of lupus, and is often autoreactive. Here we show, using RNAseq and in vitro and in vivo analyses, signals that are required for promoting B 2R cell...

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