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Article

Upregulated Fcrl5 disrupts B cell anergy and causes autoimmune disease

28 Sept 2023

Abstract excerpt

B cell anergy plays a critical role in maintaining self-tolerance by inhibiting autoreactive B cell activation to prevent autoimmune diseases. Here, we demonstrated that Fc receptor-like 5 (Fcrl5) upregulation contributes to autoimmune disease pathogenesis by disrupting B cell anergy. Fcrl5-a gene whose homologs are associated with human autoimmune diseases-is highly expressed in age/autoimmunity-associated B...

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PMID: 37841260
DOI: 10.3389/fimmu.2023.1276014

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