Article

Therapy Induced Tumor Senescence Model

2022-10-24

Abstract excerpt

Senescent cell accumulation and defective clearance of the senescent cells by the immune system occur with aging and increase the prevalence of diseases like cancer. Anti-tumor therapies can induce senescence in the tumor cells. Senescence Associated Secretory Phenotypes (SASP) secretion by these senescent tumor cells activates the innate NK cells which can detect and eliminate them. Mechanisms are unclear about h...

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Literature Corpus work: 5e58c5c4-5d91-52b7-a8f5-20d56f5b9621
DOI: 10.1101/2022.10.23.513380

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