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Targeting senescent cells with NKG2D-CAR T cells

4 May 2024

Abstract excerpt

This study investigates the efficacy of NKG2D chimeric antigen receptor (CAR) engineered T cells in targeting and eliminating stress-induced senescent cells in vitro. Cellular senescence contributes to age-related tissue decline and is characterized by permanent cell cycle arrest and the senescence-associated secretory phenotype (SASP). Immunotherapy, particularly CAR-T cell therapy, emerges as a promising...

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PMID: 38704364
DOI: 10.1038/s41420-024-01976-7

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