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Senescence, NK cells, and cancer: navigating the crossroads of aging and disease

4 Apr 2025

Abstract excerpt

Cellular senescence, a state of stable cell cycle arrest, acts as a double-edged sword in cancer biology. In young organisms, it acts as a barrier against tumorigenesis, but in the aging population, it may facilitate tumor growth and metastasis through the senescence-associated secretory phenotype (SASP). Natural killer (NK) cells play a critical role in the immune system, particularly in the surveillance,...

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PMID: 40255394
DOI: 10.3389/fimmu.2025.1565278

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