Article

Co-option of mitochondrial nucleic acid sensing pathways by HSV-1 UL12.5 for reactivation from latent Infection

2024-07-07

Abstract excerpt

<h4>Summary</h4> Although viruses subvert innate immune pathways for their replication, there is evidence they can also co-opt anti-viral responses for their benefit. The ubiquitous human pathogen, Herpes Simplex Virus-1 (HSV-1), encodes a protein (UL12.5) that induces the release of mitochondrial nucleic acid into the cytosol, which activates immune sensing pathways and reduces productive replication in non-neur...

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Literature Corpus work: 27eb2e17-b916-5951-a52f-9953e7d6ae7f
DOI: 10.1101/2024.07.06.601241

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